Social Cognition in Alzheimer’s disease: A separate construct contributing to dependence
Identifieur interne : 000846 ( Main/Exploration ); précédent : 000845; suivant : 000847Social Cognition in Alzheimer’s disease: A separate construct contributing to dependence
Auteurs : Stephanie Cosentino ; Laura B. Zahodne ; Jason Brandt [États-Unis] ; Deborah Blacker [États-Unis] ; Marilyn Albert [États-Unis] ; Bruno Dubois [France] ; Yaakov SternSource :
- Alzheimer's & dementia : the journal of the Alzheimer's Association [ 1552-5260 ] ; 2014.
Abstract
The extent to which social cognitive changes reflect a discrete constellation of symptoms dissociable from general cognitive changes in Alzheimer’s disease (AD) is unclear. Moreover, whether social cognitive symptoms contribute to disease severity and progression is unknown. The current multicenter study investigated cross-sectional and longitudinal associations between social cognition, general cognition, and dependence in 517 participants with Probable AD. Participants were followed every 6-months for 5.5 years. Results from multivariate latent growth curve models adjusted for sex, age, education, depression, and recruitment site revealed that social cognition and general cognition were unrelated cross-sectionally and over time. However, baseline levels of each were independently related to dependence, and change values of each were independently related to change in dependence. These findings highlight the separability of social and general cognition in AD. Results underscore the relevance of considering social cognition when modeling disease and estimating clinical outcomes related to patient disability.
Url:
DOI: 10.1016/j.jalz.2013.12.021
PubMed: 24656839
PubMed Central: 3980672
Affiliations:
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Institut National de la Santé et de la Recherche Médicale, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>UMRS 975 – Institut du Cerveau et de la Moelle Epinière - Institut National de la Santé et de la Recherche Médicale, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A7">Institut de la Mémoire et de la Maladie d’Alzheimer, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut de la Mémoire et de la Maladie d’Alzheimer, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A8">Centre de Références Démences Rares, Groupe Hospitalier Pitié-Salpêtrière, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre de Références Démences Rares, Groupe Hospitalier Pitié-Salpêtrière, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Stern, Yaakov" sort="Stern, Yaakov" uniqKey="Stern Y" first="Yaakov" last="Stern">Yaakov Stern</name><affiliation><nlm:aff id="A1">Cognitive Neuroscience Division, Department of Neurology and Taub Institute for Research on Alzheimer’s Disease and The Aging Brain, Columbia University College of Physicians and Surgeons</nlm:aff><wicri:noCountry code="subfield">Columbia University College of Physicians and Surgeons</wicri:noCountry></affiliation></author></analytic><series><title level="j">Alzheimer's & dementia : the journal of the Alzheimer's Association</title><idno type="ISSN">1552-5260</idno><idno type="eISSN">1552-5279</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P2">The extent to which social cognitive changes reflect a discrete constellation of symptoms dissociable from general cognitive changes in Alzheimer’s disease (AD) is unclear. Moreover, whether social cognitive symptoms contribute to disease severity and progression is unknown. The current multicenter study investigated cross-sectional and longitudinal associations between social cognition, general cognition, and dependence in 517 participants with Probable AD. Participants were followed every 6-months for 5.5 years. Results from multivariate latent growth curve models adjusted for sex, age, education, depression, and recruitment site revealed that social cognition and general cognition were unrelated cross-sectionally and over time. However, baseline levels of each were independently related to dependence, and change values of each were independently related to change in dependence. These findings highlight the separability of social and general cognition in AD. Results underscore the relevance of considering social cognition when modeling disease and estimating clinical outcomes related to patient disability.</p></div></front></TEI><affiliations><list><country><li>France</li><li>États-Unis</li></country><region><li>Maryland</li><li>Massachusetts</li><li>Île-de-France</li></region><settlement><li>Paris</li></settlement><orgName><li>Université Pierre-et-Marie-Curie</li></orgName></list><tree><noCountry><name sortKey="Cosentino, Stephanie" sort="Cosentino, Stephanie" uniqKey="Cosentino S" first="Stephanie" last="Cosentino">Stephanie Cosentino</name><name sortKey="Stern, Yaakov" sort="Stern, Yaakov" uniqKey="Stern Y" first="Yaakov" last="Stern">Yaakov Stern</name><name sortKey="Zahodne, Laura B" sort="Zahodne, Laura B" uniqKey="Zahodne L" first="Laura B." last="Zahodne">Laura B. Zahodne</name></noCountry><country name="États-Unis"><region name="Maryland"><name sortKey="Brandt, Jason" sort="Brandt, Jason" uniqKey="Brandt J" first="Jason" last="Brandt">Jason Brandt</name></region><name sortKey="Albert, Marilyn" sort="Albert, Marilyn" uniqKey="Albert M" first="Marilyn" last="Albert">Marilyn Albert</name><name sortKey="Albert, Marilyn" sort="Albert, Marilyn" uniqKey="Albert M" first="Marilyn" last="Albert">Marilyn Albert</name><name sortKey="Blacker, Deborah" sort="Blacker, Deborah" uniqKey="Blacker D" first="Deborah" last="Blacker">Deborah Blacker</name><name sortKey="Brandt, Jason" sort="Brandt, Jason" uniqKey="Brandt J" first="Jason" last="Brandt">Jason Brandt</name></country><country name="France"><region name="Île-de-France"><name sortKey="Dubois, Bruno" sort="Dubois, Bruno" uniqKey="Dubois B" first="Bruno" last="Dubois">Bruno Dubois</name></region><name sortKey="Dubois, Bruno" sort="Dubois, Bruno" uniqKey="Dubois B" first="Bruno" last="Dubois">Bruno Dubois</name><name sortKey="Dubois, Bruno" sort="Dubois, Bruno" uniqKey="Dubois B" first="Bruno" last="Dubois">Bruno Dubois</name><name sortKey="Dubois, Bruno" sort="Dubois, Bruno" uniqKey="Dubois B" first="Bruno" last="Dubois">Bruno Dubois</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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